读丨猫 α-氯醛糖(Alpha-Chloralose)中毒

Alpha-Chloralose Toxicosis

https://journals.sagepub.com/doi/full/10.1177/1098612X221107787

Alpha-Chloralose

氯醛糖

氯醛缩葡萄糖

读丨猫 α-氯醛糖(Alpha-Chloralose)中毒

Abstract 摘要

Objectives 目的

The aim of this study was to describe the clinical picture in cats with alpha-chloralose (AC) intoxication and to confirm AC in serum from suspected cases of AC poisoning.

– 猫α氯醛糖的中毒临床表现

– 血清α氯醛糖

读丨猫 α-氯醛糖(Alpha-Chloralose)中毒

Methods 方法

Suspected cases of AC poisoning were identified in patient records from a small animal university hospital from January 2014 to February 2020. Clinical signs of intoxication described in respective records were compiled, the cats were graded into four intoxication severity scores and hospitalisation time and mortality were recorded. Surplus serum from select cases in late 2019 and early 2020 was analysed to detect AC with a quantitative ultra-high performance liquid chromatography tandem mass spectrometry analysis, and the AC concentration was compared with the respective cat’s intoxication severity score.

2014年1月至2020年2月,
在一家小型动物大学医院的病历中发现疑似α氯醛糖中毒的病例。

收集各自记录中描述的中毒临床症状,
将猫分为四个中毒严重程度评分,
并记录住院时间和死亡率。

对2019年底和2020年初选定病例的剩余血清进行分析,
采用定量超高高效液相色谱串联质谱分析(quantitative ultra-high performance liquid chromatography tandem mass spectrometry analysis)检测α氯醛糖,
并将α氯醛糖浓度与各猫的中毒严重程度评分进行比较。

读丨猫 α-氯醛糖(Alpha-Chloralose)中毒

Results 结果

Serum from 25 cats was available for analysis and AC poisoning was confirmed in all. Additionally, 78 cats with a clinical suspicion of AC intoxication were identified in the patient records, most of which presented from September to April. The most common signs of intoxication were ataxia, tremors, cranial nerve deficits and hyperaesthesia. The prevalence of clinical signs and intoxication severity differed from what has previously been reported, with our population presenting with less severe signs and no deaths due to intoxication. The majority had a hospitalisation time

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