国际兽医癫痫工作组共识建议:欧洲犬癫痫的药物治疗丨非尔氨脂丨翻译节选

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GuzzleHttp\Exception\RequestException: cURL error 0: The connection unexpectedly failed without providing an error. The request would have been retried, but attempting to rewind the request body failed. Exception: RuntimeException: Stream is not seekable in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php:204
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php(193): GuzzleHttp\Psr7\Stream->seek(0)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(517): GuzzleHttp\Psr7\Stream->rewind()
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#18 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘1e287686359de28…’, Object(GuzzleHttp\Psr7\Stream))
#22 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘1e287686359de28…’)
#23 {main} (see https://curl.haxx.se/libcurl/c/libcurl-errors.html) in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php:201
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(524): GuzzleHttp\Handler\CurlFactory::createRejection(Object(GuzzleHttp\Handler\EasyHandle), Array)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#18 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘1e287686359de28…’, Object(GuzzleHttp\Psr7\Stream))
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘1e287686359de28…’)
#22 {main}” width=”627″ height=”373″>

国际兽医癫痫工作组共识建议:欧洲犬癫痫的药物治疗

Sofie F.M. Bhatti1*, Luisa De Risio2 , Karen Mu~nana3 , Jacques Penderis4 , Veronika M. Stein5 , Andrea Tipold5 , Mette Berendt6 , Robyn G. Farquhar7 , Andrea Fischer8 , Sam Long9 , Wolfgang L”oscher10, Paul J.J. Mandigers11, Kaspar Matiasek12, Akos Pakozdy13, Edward E. Patterson14, Simon Platt15, Michael Podell16, Heidrun Potschka17, Clare Rusbridge18,19 and Holger A. Volk20

翻译 By @苏苏苏苏乔

校正 By @宠物神经科医生高健

Felbamate 非尔氨脂

One veterinary study evaluated the efficacy of felbamate as an adjunct to PB in 6 dogs with focal idiopathic epilepsy [100]. According to Charalambous et al. (2014) [17], the study demonstrated overall moderate/high risk of bias. On this basis it was concluded that there is currently insufficient evidence to recommending the use of felbamate as an add-on AED. Felbamate should be reserved for dogs refractory to the other more thoroughly investigated and safer AEDs in this species and as such this is a 4th or 5th line option. In the clinical study by Ruehlmann et al., (2001) [100] adverse effects noted included keratoconjunctivitis sicca and mild blood dyscrasias (Table 2).

一项兽医研究对6例局灶性特发性癫痫犬用非尔氨脂作为苯巴比妥辅助药物的疗效进行了评估[100]。Charalambous等(2014)[17]认为该研究总体偏倚风险为中/高。在此基础上得出的结论是,目前没有足够的证据建议使用非尔氨脂可以作为辅助抗癫痫药物。非尔氨脂应该保留给对其他更彻底和更安全的抗癫痫药物不耐受的犬,因此这是第4或第5线选择。在Ruehlmann等(2001)[100]的临床研究中,不良反应包括干燥性角膜结膜炎和轻度血液恶液质(表2)。

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GuzzleHttp\Exception\RequestException: cURL error 0: The connection unexpectedly failed without providing an error. The request would have been retried, but attempting to rewind the request body failed. Exception: RuntimeException: Stream is not seekable in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php:204
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php(193): GuzzleHttp\Psr7\Stream->seek(0)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(517): GuzzleHttp\Psr7\Stream->rewind()
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#18 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘be0f87b3f1c946d…’, Object(GuzzleHttp\Psr7\Stream))
#22 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘be0f87b3f1c946d…’)
#23 {main} (see https://curl.haxx.se/libcurl/c/libcurl-errors.html) in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php:201
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(524): GuzzleHttp\Handler\CurlFactory::createRejection(Object(GuzzleHttp\Handler\EasyHandle), Array)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#18 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘be0f87b3f1c946d…’, Object(GuzzleHttp\Psr7\Stream))
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘be0f87b3f1c946d…’)
#22 {main}” width=”1225″ height=”44″>

Felbamate is a dicarbamate AED released for use in humans in 1993 for the control of focal seizures. Its mechanism of action is multiple such as inhibition of glycine-enhanced NMDA-induced intracellular calcium currents [134], blockade of voltage-gated sodium channels and inhibition of voltage –gated calcium currents [133].

非尔氨脂是一种双氨基甲酸酯抗癫痫药物(dicarbamate AED),于1993年发布用于人类,用于控制局灶性抽搐发作。其作用机制多种多样,如,抑制甘氨酸增强的NMDA诱导的细胞内钙离子电流[134],阻滞电压门控钠离子通道,和抑制电压门控钙离子电流[133]。

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GuzzleHttp\Exception\RequestException: cURL error 0: The connection unexpectedly failed without providing an error. The request would have been retried, but attempting to rewind the request body failed. Exception: RuntimeException: Stream is not seekable in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php:204
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php(193): GuzzleHttp\Psr7\Stream->seek(0)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(517): GuzzleHttp\Psr7\Stream->rewind()
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#18 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ’84f51d528727b72…’, Object(GuzzleHttp\Psr7\Stream))
#22 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ’84f51d528727b72…’)
#23 {main} (see https://curl.haxx.se/libcurl/c/libcurl-errors.html) in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php:201
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(524): GuzzleHttp\Handler\CurlFactory::createRejection(Object(GuzzleHttp\Handler\EasyHandle), Array)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#18 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ’84f51d528727b72…’, Object(GuzzleHttp\Psr7\Stream))
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ’84f51d528727b72…’)
#22 {main}” width=”1225″ height=”44″>

In 1993, felbamate was marketed as a safe AED, which lacked demonstrable toxic side effects and did not require laboratory monitoring in humans. However, within a year of its release it became evident that felbamate was associated with an unacceptable incidence of life-threatening side effects [12], such as anorexia, weight loss, vomiting, headache, irritability. Moreover, aplastic anemia and fatal hepatotoxicity were also described [55, 134].

1993年,非尔氨脂作为一种安全的抗癫痫药物上市,没有明显的毒副作用,也不需要在人体中进行实验室监测。然而,在其发布的一年内,发现非尔氨脂与无法接受的危及生命的副作用的发生率有明显相关[12],如厌食症、体重减轻、呕吐、头痛、易怒。此外,也有再生障碍性贫血(aplastic anemia)和致死性肝毒性(fatal hepatotoxicity )的报道[55,134]。

<img data-src="
Warning: curl_setopt_array(): Unable to create temporary file. in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php on line 59
GuzzleHttp\Exception\RequestException: cURL error 0: The connection unexpectedly failed without providing an error. The request would have been retried, but attempting to rewind the request body failed. Exception: RuntimeException: Stream is not seekable in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php:204
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php(193): GuzzleHttp\Psr7\Stream->seek(0)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(517): GuzzleHttp\Psr7\Stream->rewind()
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#18 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘497e3e45c971cd3…’, Object(GuzzleHttp\Psr7\Stream))
#22 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘497e3e45c971cd3…’)
#23 {main} (see https://curl.haxx.se/libcurl/c/libcurl-errors.html) in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php:201
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(524): GuzzleHttp\Handler\CurlFactory::createRejection(Object(GuzzleHttp\Handler\EasyHandle), Array)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#18 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘497e3e45c971cd3…’, Object(GuzzleHttp\Psr7\Stream))
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘497e3e45c971cd3…’)
#22 {main}” width=”1225″ height=”44″>

Pharmacokinetic interactions between felbamate and other AEDs have been well described. E.g. felbamate raises concurrent PB serum levels in a dose-dependent manner [12], and the elimination of felbamate was noted to be strikingly reduced when given with gabapentin [50]. Felbamate is mainly metabolized by the liver [88] and should therefore not be used in dogs with preexisting hepatic disease. Felbamate has an elimination half-life of 5-7h.

非尔氨脂和其他抗癫痫药物之间的药代动力学相互作用已有很好描述。例如,非尔氨脂以剂量依赖性的方式提高了血清中同时存在的苯巴比妥水平[12],并且当与加巴喷丁一起服用时,非尔氨脂的消除时间明显缩短[50]。非尔氨脂主要由肝脏代谢[88],因此不应用于有肝脏病史的犬。非尔氨脂的消除半衰期为5-7小时。

<img data-src="
Warning: curl_setopt_array(): Unable to create temporary file. in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php on line 59
GuzzleHttp\Exception\RequestException: cURL error 0: The connection unexpectedly failed without providing an error. The request would have been retried, but attempting to rewind the request body failed. Exception: RuntimeException: Stream is not seekable in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php:204
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php(193): GuzzleHttp\Psr7\Stream->seek(0)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(517): GuzzleHttp\Psr7\Stream->rewind()
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#18 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘5d0bb7bb0edce8f…’, Object(GuzzleHttp\Psr7\Stream))
#22 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘5d0bb7bb0edce8f…’)
#23 {main} (see https://curl.haxx.se/libcurl/c/libcurl-errors.html) in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php:201
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(524): GuzzleHttp\Handler\CurlFactory::createRejection(Object(GuzzleHttp\Handler\EasyHandle), Array)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#18 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘5d0bb7bb0edce8f…’, Object(GuzzleHttp\Psr7\Stream))
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘5d0bb7bb0edce8f…’)
#22 {main}” width=”1225″ height=”44″>

The recommended oral starting dose in dogs is 20 mg/kg TID, increasing to 400-600mg/day every 1-2 weeks [1]. Haematologic evaluations and biochemistry panels (esp. liver enzyme concentrations) should be performed before felbamate therapy is initiated and during therapy. This is especially important in animals receiving concurrent PB. In humans, the signs of aplastic anaemia and liver failure are usually seen during the first 6-12 months of therapy. In dogs, a minimum of monthly blood tests should be performed for this period of time, following-up every 6-12 months after this. Currently, felbamate is not available in every country.

推荐的犬口服起始剂量为 20 mg/kg TID,每1-2周增加至400-600 mg/天[1]。在非尔氨脂治疗开始前和治疗期间应进行血液学评估和生化检查(尤其是肝酶浓度)。在同时使用苯巴比妥的动物中尤为重要。在人类中,再生障碍性贫血和肝功能衰竭的症状通常在治疗的前的6-12个月出现。在这段时间内,应对犬每月至少一次进行血液检查,此后每6-12个月复查一次。目前不是每个国家都能买到非尔氨脂。

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GuzzleHttp\Exception\RequestException: cURL error 0: The connection unexpectedly failed without providing an error. The request would have been retried, but attempting to rewind the request body failed. Exception: RuntimeException: Stream is not seekable in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php:204
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php(193): GuzzleHttp\Psr7\Stream->seek(0)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(517): GuzzleHttp\Psr7\Stream->rewind()
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#18 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘5c003a816fbbd54…’, Object(GuzzleHttp\Psr7\Stream))
#22 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘5c003a816fbbd54…’)
#23 {main} (see https://curl.haxx.se/libcurl/c/libcurl-errors.html) in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php:201
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(524): GuzzleHttp\Handler\CurlFactory::createRejection(Object(GuzzleHttp\Handler\EasyHandle), Array)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#18 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘5c003a816fbbd54…’, Object(GuzzleHttp\Psr7\Stream))
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘5c003a816fbbd54…’)
#22 {main}” width=”1225″ height=”44″>

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