国际兽医癫痫工作组共识建议:欧洲犬癫痫的药物治疗丨加巴喷丁丨翻译节选

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GuzzleHttp\Exception\RequestException: cURL error 0: The connection unexpectedly failed without providing an error. The request would have been retried, but attempting to rewind the request body failed. Exception: RuntimeException: Stream is not seekable in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php:204
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php(193): GuzzleHttp\Psr7\Stream->seek(0)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(517): GuzzleHttp\Psr7\Stream->rewind()
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#18 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘3c32eebc5d5f4db…’, Object(GuzzleHttp\Psr7\Stream))
#22 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘3c32eebc5d5f4db…’)
#23 {main} (see https://curl.haxx.se/libcurl/c/libcurl-errors.html) in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php:201
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(524): GuzzleHttp\Handler\CurlFactory::createRejection(Object(GuzzleHttp\Handler\EasyHandle), Array)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#18 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘3c32eebc5d5f4db…’, Object(GuzzleHttp\Psr7\Stream))
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘3c32eebc5d5f4db…’)
#22 {main}” width=”615″ height=”349″>

国际兽医癫痫工作组共识建议:欧洲犬癫痫的药物治疗

Sofie F.M. Bhatti1*, Luisa De Risio2 , Karen Mu~nana3 , Jacques Penderis4 , Veronika M. Stein5 , Andrea Tipold5 , Mette Berendt6 , Robyn G. Farquhar7 , Andrea Fischer8 , Sam Long9 , Wolfgang L”oscher10, Paul J.J. Mandigers11, Kaspar Matiasek12, Akos Pakozdy13, Edward E. Patterson14, Simon Platt15, Michael Podell16, Heidrun Potschka17, Clare Rusbridge18,19 and Holger A. Volk20

翻译 By @苏苏苏苏乔

校正 By @宠物神经科医生高健

Gabapentin 加巴喷丁

Two prospective studies evaluated the efficacy of oral gabapentin as an adjunct to other AEDs, giving a combined sample size of 28 dogs [44, 89]. According to Charalambous et al. (2014) [17], one study demonstrated an overall moderate/high risk of bias and the other one demonstrated an overall high risk of bias. None of the studies demonstrated an increased likelihood that the majority of the dogs were treated successfully by oral administration of gabapentin. Accordingly, there is currently overall insufficient evidence for recommending the use of gabapentin as an adjunct AED [17]. If used, the recommended oral dosage of gabapentin in dogs is 10 to 20 mg/kg TID, although dose reduction may be necessary in patients with reduced renal function [9]. Sedation and ataxia were the most common side effects reported in dogs [44, 89] (Table 2).

两项前瞻性研究评估了口服加巴喷丁作为其他抗抽搐药辅助药的疗效,共包含28例犬的样本[44,89]。Charalambous等人(2014)[17]一项研究显示总体偏倚风险为中/高,另一项研究显示总体偏倚风险为高。没有一项研究表明,大多数犬通过口服加巴喷丁的成功治疗的可能性增加。因此,目前推荐加巴喷丁作为辅助抗癫痫药物的证据总体不足[17]。如果使用加巴喷丁,推荐犬口服剂量为10-20 mg/kg TID,但肾功能减退的病患可能需要减少剂量[9]。犬中最常见的副作用镇静和共济失调44,89。

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GuzzleHttp\Exception\RequestException: cURL error 0: The connection unexpectedly failed without providing an error. The request would have been retried, but attempting to rewind the request body failed. Exception: RuntimeException: Stream is not seekable in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php:204
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php(193): GuzzleHttp\Psr7\Stream->seek(0)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(517): GuzzleHttp\Psr7\Stream->rewind()
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#18 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘168ac208a00ff17…’, Object(GuzzleHttp\Psr7\Stream))
#22 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘168ac208a00ff17…’)
#23 {main} (see https://curl.haxx.se/libcurl/c/libcurl-errors.html) in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php:201
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(524): GuzzleHttp\Handler\CurlFactory::createRejection(Object(GuzzleHttp\Handler\EasyHandle), Array)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#18 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘168ac208a00ff17…’, Object(GuzzleHttp\Psr7\Stream))
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘168ac208a00ff17…’)
#22 {main}” width=”1212″ height=”45″>

Gabapentin has been approved in people in Europe and by the US Food and Drug Administration (FDA) since 1993 for adjunctive treatment of focal seizures with or without secondary generalisation and for the treatment of post-herpetic neuralgia [9]. Its precise mechanism of action is unclear, but is believed that much of its anticonvulsant effect is because of its binding to a specific modulatory protein of voltage-gated calcium channels, which results in decreased release of excitatory neurotransmitters [112]. In humans, gabapentin is entirely excreted by the kidneys. In dogs, renal excretion occurs after a partial hepatic metabolism. The elimination half-life is 3-4h.

自1993年以来,加巴喷丁已获得欧洲和美国食品和药物管理局(FDA)的批准用于伴有或不伴有继发性全身发作的局灶性抽搐发作的辅助治疗以及疱疹后神经痛的治疗[9]。其确切的作用机制尚不清楚,但一般认为其抗惊厥作用主要是由于其与电压门控钙离子通道的特定调节蛋白结合,导致兴奋性神经递质的释放减少[112]。在人类中,加巴喷丁完全由肾脏排出。在犬,肾脏排泄发生在部分性肝脏代谢之后。清除半衰期为3-4小时。

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GuzzleHttp\Exception\RequestException: cURL error 0: The connection unexpectedly failed without providing an error. The request would have been retried, but attempting to rewind the request body failed. Exception: RuntimeException: Stream is not seekable in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php:204
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php(193): GuzzleHttp\Psr7\Stream->seek(0)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(517): GuzzleHttp\Psr7\Stream->rewind()
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#18 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ’77c578be7559664…’, Object(GuzzleHttp\Psr7\Stream))
#22 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ’77c578be7559664…’)
#23 {main} (see https://curl.haxx.se/libcurl/c/libcurl-errors.html) in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php:201
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(524): GuzzleHttp\Handler\CurlFactory::createRejection(Object(GuzzleHttp\Handler\EasyHandle), Array)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#18 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ’77c578be7559664…’, Object(GuzzleHttp\Psr7\Stream))
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ’77c578be7559664…’)
#22 {main}” width=”1212″ height=”45″>

Although information in veterinary medicine is limited, pharmacokinetic interactions of gabapentin are unlikely to occur as the drug has negligible protein binding and does not induce hepatic cytochrome P450 family enzymes [95]. In humans, the elimination of felbamate was noted to be significantly reduced when given with gabapentin [50]. The most common adverse effects in humans include dizziness, somnolence and fatigue [9]. These effects seem to be dose-dependent and resolve within the first few weeks of treatment. No serious idiosyncratic reactions or organ toxicities have been identified in humans or animals [60].

虽然兽医医学方面的信息有限,但加巴喷丁的药代动力学相互作用不太可能发生,因为该药物的蛋白质结合可以忽略不计,并且不会诱导肝细胞色素P450族酶[95]。在人类中,加巴喷丁可显著降低非氨酯的清除[50]。人类最常见的不良反应包括头晕、嗜睡和疲劳[9]。这些影响似乎是剂量依赖性的,并在治疗的最初几周内消退。在人类或动物中未发现严重的特质性反应(idiosyncratic reactions)或器官毒性[60]。

<img data-src="
Warning: curl_setopt_array(): Unable to create temporary file. in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php on line 59
GuzzleHttp\Exception\RequestException: cURL error 0: The connection unexpectedly failed without providing an error. The request would have been retried, but attempting to rewind the request body failed. Exception: RuntimeException: Stream is not seekable in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php:204
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\psr7\src\Stream.php(193): GuzzleHttp\Psr7\Stream->seek(0)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(517): GuzzleHttp\Psr7\Stream->rewind()
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#18 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘7caf49f2e16aaaf…’, Object(GuzzleHttp\Psr7\Stream))
#22 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘7caf49f2e16aaaf…’)
#23 {main} (see https://curl.haxx.se/libcurl/c/libcurl-errors.html) in C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php:201
Stack trace:
#0 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(524): GuzzleHttp\Handler\CurlFactory::createRejection(Object(GuzzleHttp\Handler\EasyHandle), Array)
#1 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(152): GuzzleHttp\Handler\CurlFactory::retryFailedRewind(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Array)
#2 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlFactory.php(105): GuzzleHttp\Handler\CurlFactory::finishError(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#3 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(201): GuzzleHttp\Handler\CurlFactory::finish(Object(GuzzleHttp\Handler\CurlMultiHandler), Object(GuzzleHttp\Handler\EasyHandle), Object(GuzzleHttp\Handler\CurlFactory))
#4 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(130): GuzzleHttp\Handler\CurlMultiHandler->processMessages()
#5 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\guzzle\src\Handler\CurlMultiHandler.php(145): GuzzleHttp\Handler\CurlMultiHandler->tick()
#6 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Handler\CurlMultiHandler->execute(true)
#7 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#8 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(269): GuzzleHttp\Promise\Promise->waitIfPending()
#9 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(226): GuzzleHttp\Promise\Promise->invokeWaitList()
#10 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#11 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(67): GuzzleHttp\Promise\Promise->wait()
#12 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(248): GuzzleHttp\Promise\Coroutine->GuzzleHttp\Promise\{closure}(true)
#13 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(224): GuzzleHttp\Promise\Promise->invokeWaitFn()
#14 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Promise.php(62): GuzzleHttp\Promise\Promise->waitIfPending()
#15 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\promises\src\Coroutine.php(103): GuzzleHttp\Promise\Promise->wait(true)
#16 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(77): GuzzleHttp\Promise\Coroutine->wait()
#17 C:\wwwroot\upimg.chonwuleyuan.com\vendor\guzzlehttp\command\src\ServiceClient.php(153): GuzzleHttp\Command\ServiceClient->execute(Object(GuzzleHttp\Command\Command))
#18 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(269): GuzzleHttp\Command\ServiceClient->__call(‘PutObject’, Array)
#19 C:\wwwroot\upimg.chonwuleyuan.com\src\Client.php(321): Qcloud\Cos\Client->__call(‘putObject’, Array)
#20 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(36): Qcloud\Cos\Client->upload(‘chonwuleyuan-12…’, ‘7caf49f2e16aaaf…’, Object(GuzzleHttp\Psr7\Stream))
#21 C:\wwwroot\upimg.chonwuleyuan.com\getcos.php(10): upload(‘http://i0.hdslb…’, ‘7caf49f2e16aaaf…’)
#22 {main}” width=”1212″ height=”45″>

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